Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Downtown Transit Center | 1116 Woodruff Rd | Cheapest | |||||
 | Indianapolis Bus Station | 1116 Woodruff Rd | Fastest | |||||
Greyhound Lines, Inc. + FlixBus | Indianapolis Bus Station | 1116 Woodruff Rd | No tags | |||||
| Indianapolis Bus Station | 1116 Woodruff Rd | No tags | |||||
| Downtown Transit Center | 1116 Woodruff Rd | No tags |
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Compare 2 ways to go from Indianapolis to Greenville
Busbud recommends taking the bus from Indianapolis to GreenvilleAmong the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes, and with fares starting at just US$70, it presents an excellent value for a comfortable ride.
Bus Indianapolis to Greenville, SC: Trip Overview
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Indianapolis to Greenville Bus
With Busbud, comparing and booking tickets for a bus from Indianapolis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Indianapolis to Greenville from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Indianapolis and Greenville?
Frequently asked questions on the trip Indianapolis - Greenville, SC
What is the distance between Indianapolis and Greenville?
The distance covered from Indianapolis to Greenville is 641 km (398 miles).
What are the departure and arrival locations for buses traveling from Indianapolis to Greenville?
Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Guadalajara Supermarket Bus Stop, in Greenville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Greenville, SC was searched and found on Sep 3, 2025 with a price of US$75To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC, as early as possible.
You can expect to pay from US$75 to US$129 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$75 which is on 2025-09-03.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Indianapolis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Greenville, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Greenville.
Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Greenville while indulging in miles on end of beautiful scenic views.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
What's the cheapest way to go from Indianapolis to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular Buses Connecting Indianapolis
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Buses Going to Indianapolis
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Popular Buses Connecting Greenville
Buses Leaving from Greenville
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Buses Going to Greenville
- Bus from Atlanta to Greenville
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- Bus from Charlotte to Greenville
- Bus Memphis - Greenville
- New Haven - Greenville
- Bus from Winston-Salem to Greenville
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Popular routes in this country
- Bus from Washington to New York City
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- New York City - Boston
- Bus from Buffalo to New York City
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- Bus Los Angeles - San Francisco
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- Atlanta - Savannah