Bus Tickets from Indianapolis to Greenville, SC

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TodaySep 2
TomorrowSep 3
from $83
ThuSep 4
FriSep 5
from $89
SatSep 6
SunSep 7
from $91
MonSep 8
TueSep 9

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: September 3 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 3 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: September 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Indianapolis to Greenville.

Bus
Average Price$70 - $234Average Duration16h 15m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$156 - $304Average Duration1d 5h
58kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 16 hours 15 minutes and with fares starting at just $70, it presents an excellent value for a comfortable ride.

6bus per day
16h 15mAverage Duration
$70Cheapest ticket
16kgCO₂ emissions

Bus Indianapolis to Greenville, SC: Trip Overview

Average ticket price$100
Average bus trip duration16h 15m
Number of daily buses6
Earliest bus departure3:35am
Distance401 miles (646 km)
Latest bus departure11:30pm

Indianapolis to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Indianapolis - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$91
09/01
No data
Today
No data
09/03
$75
09/04
No data
09/05
$82
09/06
No data
09/07
$84
busbud logoThe cheapest trip from Indianapolis to Greenville, SC was searched and found on Sep 3, 2025 with a price of $75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC, as early as possible.

You can expect to pay from $75 to $129 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $75 which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Indianapolis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Indianapolis to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Greenville, SC to Indianapolis

You can also go to Greenville, SC by train

Train from Indianapolis to Greenville, SC

Why choose Busbud?

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