Bus Tickets from Greenville, SC to Columbus, OH

Next departures

Next departures for Greenville to Columbus on August 31
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Columbus (E Mound St)CheapestFastest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
100 E Rich StNo tags
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
100 E Rich StNo tags

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Bus Greenville, SC to Columbus, OH: Trip Overview

Average Ticket PriceUS$104
Average Bus Trip Duration17h
Number of daily buses4
Earliest bus departure2:45pm
Distance573 km
Latest bus departure10:00pm

Greenville to Columbus Bus

Busbud helps you find a bus from Greenville to Columbus. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Columbus.

Whether it is cheap bus tickets or more luxurious buses going to Columbus from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville, SC - Columbus, OH

  1. What is the travel distance from Greenville to Columbus?

    It's about 572 km (355 miles) from Greenville to Columbus.

  2. What are the departure and arrival locations for buses traveling from Greenville to Columbus?

    Buses departing from Guadalajara Supermarket Bus Stop in Greenville will take you to Columbus Bus Station in Columbus.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
US$182
08-30
US$75
Today
US$116
09-01
No data
09-02
No data
09-03
No data
09-04
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09-05
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busbud logoThe cheapest trip from Greenville, SC to Columbus, OH was searched and found on Aug 30, 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Columbus, OH, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Columbus!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Columbus.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Columbus.

Tune out to the fine sounds of your best music playlist on your bus trip from Greenville to Columbus while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Greenville, SC by bus?

Bus from Columbus, OH to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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