Bus Tickets from Greenville, SC to Indianapolis

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TodaySep 2
TomorrowSep 3
ThuSep 4
FriSep 5
from US$81
SatSep 6
SunSep 7
MonSep 8
TueSep 9

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 5 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 6 at
    Destination city: Indianapolis
    Destination location: Indianapolis Northeast
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 5 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 6 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 6 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 6 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 6 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Greenville to Indianapolis

Bus
Average PriceUS$71 - US$155Average Duration19h 10m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$139 - US$258Average Duration1d 2h
58kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to Indianapolis

Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 19 hours 10 minutes, and with fares starting at just US$71, it presents an excellent value for a comfortable ride.

8bus per day
19h 10mAverage Duration
US$71Cheapest ticket
16kgCO₂ emissions

Bus Greenville, SC to Indianapolis: Trip Overview

Average Ticket PriceUS$96
Average Bus Trip Duration19h 10m
Number of daily buses8
Earliest bus departure8:40am
Distance646 km
Latest bus departure10:00pm

Greenville to Indianapolis Bus

Busbud helps you find a bus from Greenville to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Indianapolis.

Discover how much the bus trip from Greenville to Indianapolis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Greenville, SC - Indianapolis

  1. How far is Greenville from Indianapolis?

    The distance covered from Greenville to Indianapolis is 641 km (398 miles).

  2. What are the departure and arrival locations for buses traveling from Greenville to Indianapolis?

    Buses traveling this route start their trip at Guadalajara Supermarket Bus Stop, in Greenville, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$86
09-01
No data
Today
No data
09-03
US$64
09-04
No data
09-05
US$73
09-06
No data
09-07
No data
busbud logoThe cheapest trip from Greenville, SC to Indianapolis was searched and found on Sep 3, 2025 with a price of US$64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.

You can expect to pay from US$64 to US$88 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$64 which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Indianapolis.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Indianapolis will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Indianapolis.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Greenville, SC to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Indianapolis to Greenville, SC

You can also go to Indianapolis by train

Train from Greenville, SC to Indianapolis

Why choose Busbud?

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