Bus Tickets from Tupelo to St. Louis

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TodayAug 21
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from $72
WedAug 27
from $71
ThuAug 28
from $69

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 26 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: August 27 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 26 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: August 26 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 26 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: August 26 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Tupelo to St. Louis: Trip Overview

Average ticket price$123
Average bus trip duration18h 20m
Number of daily buses2
Earliest bus departure5:35am
Distance314 miles (506 km)
Latest bus departure9:35pm

Tupelo to St. Louis Bus

Busbud helps you find a bus from Tupelo to St. Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Tupelo to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Tupelo to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Tupelo - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/19
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08/20
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Today
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08/26
$64
busbud logoThe cheapest trip from Tupelo to St. Louis was searched and found on Aug 26, 2025 with a price of $64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to St. Louis, as early as possible.

You can expect to pay from $64 to $64 for a bus ticket from Tupelo to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $64 which is on 2025-08-26.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tupelo and St. Louis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Tupelo to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Tupelo to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Tupelo by bus?

Bus from St. Louis to Tupelo

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