Bus Tickets from Boston, MA, US to Florence, SC, US

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TodayAug 17
from $98
TomorrowAug 18
TueAug 19
from $83
WedAug 20
ThuAug 21
FriAug 22
SatAug 23
from $94
SunAug 24

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 19 at
    Departure city: Boston
    Departure location: 151 Steel Pl, Cambridge
    Arrival time: August 20 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 19 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 20 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 19 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 20 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 19 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 20 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 19 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 21 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Boston to Florence.

Bus
Average Price$83 - $226Average Duration22h 30m
29kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$142 - $779Average Duration18h 52m
106kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Boston to Florence

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 22 hours 30 minutes and with fares starting at just $83, it presents an excellent value for a comfortable ride.

5bus per day
22h 30mAverage Duration
$83Cheapest ticket
29kgCO₂ emissions

Bus Boston, MA, US to Florence, SC, US: Trip Overview

Average ticket price$144
Average bus trip duration22h 30m
Number of daily buses5
Earliest bus departure1:30am
Distance731 miles (1178 km)
Latest bus departure10:00pm

Boston to Florence Bus

With Busbud, comparing and booking tickets for a bus from Boston to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Boston to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Boston, MA, US - Florence, SC, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/15
$159
08/16
$130
Today
$102
08/18
No data
08/19
No data
08/20
No data
08/21
No data
08/22
No data
busbud logoThe cheapest trip from Boston, MA, US to Florence, SC, US was searched and found on Aug 17, 2025 with a price of $102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Florence, SC, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Boston to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Boston to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Florence.

Make a music playlist for your bus ride from Boston to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Boston, MA, US to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston, MA, US by bus?

Bus from Boston, MA, US to Florence, SC, US

You can also go to Florence, SC, US by train

Train from Boston, MA, US to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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