Trains tickets from Durham, NC, US to Buffalo, NY

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TodayAug 15
TomorrowAug 16
SunAug 17
MonAug 18
TueAug 19
WedAug 20
from $249
ThuAug 21
FriAug 22

Trains leaving Wednesday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: August 20 at
    Departure city: Durham
    Departure location: Durham Station
    Arrival time: August 21 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: August 20 at
    Departure city: Durham
    Departure location: Durham Station
    Arrival time: August 21 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: August 20 at
    Departure city: Durham
    Departure location: Durham Station
    Arrival time: August 21 at
    Destination city: Buffalo
    Destination location: Exchange Street Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: August 20 at
    Departure city: Durham
    Departure location: Durham Station
    Arrival time: August 21 at
    Destination city: Buffalo
    Destination location: Exchange Street Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:

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Compare 2 ways to go from Durham to Buffalo.

Bus
Average Price$104 - $299Average Duration21h 35m
19kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$166 - $359Average Duration1d 6h
70kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Durham to Buffalo

Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 21 hours 35 minutes and with fares starting at just $104, it presents an excellent value for a comfortable ride.

11bus per day
21h 35mAverage Duration
$104Cheapest ticket
19kgCO₂ emissions

Train Durham, NC, US to Buffalo, NY: Trip Overview

Please note, this information is subject to change.

Average ticket price$251
Average train trip duration1d 6h
Number of daily trains2
Earliest train departure9:27am
Distance477 miles (768 km)

Durham to Buffalo Train

With Busbud, comparing and booking tickets for a train from Durham to Buffalo is a breeze. Browse through an extensive selection of train fares and train schedules to find the best deals.

Train service from Durham to Buffalo will be provided by the most trusted companies.

Discover how much the train trip from Durham to Buffalo will cost you. Use our filters and sorting features to find the cheapest train tickets or high-end trains.

Frequently asked questions for your trip Durham, NC, US - Buffalo, NY

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/13
No data
08/14
No data
Today
$281
08/16
No data
08/17
No data
08/18
$241
08/19
$159
08/20
$239
busbud logoThe cheapest trip from Durham, NC, US to Buffalo, NY was searched and found on Aug 19, 2025 with a price of $159

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Buffalo, NY, as early as possible.

You can expect to pay from $159 to $372 for a train ticket from Durham, NC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $159 which is on 2025-08-19.

About Train Travel

Train Travel Tips

Taking the fastest trains allows you to travel at speeds greater than 300 km/h. Taking a trip from Durham to Buffalo is not only much quicker but more comfortable too! You can usually travel directly to the city centre and save time while you're at it.

No matter if you plan to take a regional or high-speed train to Buffalo, the planet will thank you. You’ll help to protect the beautiful landscapes that will unfold before your very eyes.

With up to 30x less CO2 emissions for your train journey between Durham and Buffalo, the train is an ecological alternative to flights or personal cars.

Make a music playlist for your train ride from Durham to Buffalo, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Railway companies played a major role as early as 1883 in the use of time zones as we know them today.

The first high-speed train line was inaugurated in 1964, in Japan, to connect Tokyo with Osaka. It was during the Olympics that the first passengers traveled aboard the Shinkansen at a speed of 210 km / h.

The magnetic levitation train (Maglev for short) is currently the fastest train in the world. With a speed of 603 km/ h, it is closely followed by the French high-speed train (574.8 km / h) which remains in 2020, the fastest train to date

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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