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- This trip is recommended because it is: Cheapest
- This trip is recommended because it is: FastestDeparture time: September 3 atDeparture city: SyracuseDeparture location: Syracuse (Regional Transportation Center)Arrival time: September 4 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: FlixBus
Vehicle: BusDuration: - Departure time: September 3 atDeparture city: SyracuseDeparture location: Syracuse (Regional Transportation Center)Arrival time: September 4 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: FlixBusVehicle: BusDuration:
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Compare 2 ways to go from Syracuse to Greenville.
Busbud recommends taking the bus from Syracuse to GreenvilleAmong the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 22 hours 20 minutes and with fares starting at just $66, it presents an excellent value for a comfortable ride.
Bus Syracuse, US to Greenville, SC: Trip Overview
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Syracuse to Greenville Bus
Busbud helps you find a bus from Syracuse to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Syracuse to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Syracuse, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Syracuse and Greenville?
Frequently asked questions for your trip Syracuse, US - Greenville, SC
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Greenville, SC was searched and found on Sep 3, 2025 with a price of $59To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC, as early as possible.
You can expect to pay from $59 to $100 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $80 which is on 2025-09-04.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Greenville!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Syracuse to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Syracuse to Greenville.
Make a music playlist for your bus ride from Syracuse to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
What's the cheapest way to go from Syracuse, US to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Greenville
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Buses Going to Greenville
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