Find coaches from Syracuse, US to Greenville, SC

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Today2 Sept
Tomorrow3 Sept
from US$66
Thu4 Sept
Fri5 Sept
Sat6 Sept
Sun7 Sept
Mon8 Sept
Tue9 Sept

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 3 September at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: 4 September at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 3 September at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: 4 September at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 3 September at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: 5 September at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 3 September at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: 4 September at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Syracuse to Greenville

Bus
Average priceUS$66 - US$247Average duration22h 20m
26kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$201 - US$231Average duration22h 18m
97kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Syracuse to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 22 hours 20 minutes and with fares starting at just US$66, it presents an excellent value for a comfortable ride.

4bus per day
22h 20mAverage duration
US$66Cheapest ticket
26kgCO₂ emissions

Bus Syracuse, US to Greenville, SC: Trip Overview

Average ticket priceUS$116
Average bus trip duration22h 20m
Number of daily buses4
Earliest bus departure10:45
Distance657 miles
Latest bus departure21:00

Syracuse to Greenville Bus

Busbud helps you find a bus from Syracuse to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Syracuse to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Syracuse, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Syracuse, US - Greenville, SC

  1. How far is Greenville from Syracuse by coach?

    The distance between Syracuse and Greenville by coach is approximately 658 miles (1060 km).

  2. What is the best way to go from Syracuse to Greenville without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/08
US$131
01/09
No data
Today
US$90
03/09
US$59
04/09
US$80
05/09
No data
06/09
US$84
07/09
No data
busbud logoThe cheapest trip from Syracuse, US to Greenville, SC was searched and found on 3 Sept 2025 with a price of US$59

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC as early as possible.

You can expect to pay from US$59 to US$138 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$59, which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Greenville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Syracuse to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Syracuse to Greenville.

Make a music playlist for your bus ride from Syracuse to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Syracuse, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Syracuse, US by bus?

Bus from Greenville, SC to Syracuse, US

You can also go to Greenville, SC by train

Train from Syracuse, US to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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