Bus Tickets from Milwaukee to La Crosse, WI

Next departures

Next departures for Milwaukee to La Crosse on September 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
St. Paul & N5th
632 17th Street NorthCheapestFastest
Megabus US
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse WI - University of Wisconsin (LSW)No tags
Jefferson Lines
St. Paul & N5th
La Crosse MTU Transit CenterNo tags
Megabus US
Milwaukee Bus Station, St. Paul & N6th road.
La Crosse St Andrew StNo tags

Accepted payments

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Compare 2 ways to go from Milwaukee to La Crosse.

Bus
Average Price$41 - $57Average Duration4h 45m
7kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average Price$27 - $315Average Duration3h 44m
26kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Milwaukee to La Crosse

Among the sustainable travel choices, the train stands out as the good way to reach La Crosse. The journey takes about 3 hours 44 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

5train per day
3h 44mAverage Duration
$27Cheapest ticket
26kgCO₂ emissions

Bus Milwaukee to La Crosse, WI: Trip Overview

Average ticket price$46
Average bus trip duration4h 45m
Number of daily buses2
Earliest bus departure8:50am
Distance175 miles (281 km)
Latest bus departure10:15am

Milwaukee to La Crosse Bus

Busbud helps you find a bus from Milwaukee to La Crosse. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Milwaukee to La Crosse.

From cheap bus tickets to more luxurious buses traveling from Milwaukee to La Crosse, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Milwaukee - La Crosse, WI

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/30
$39
08/31
$39
Today
$39
09/02
$39
09/03
$39
09/04
$39
09/05
$43
09/06
$43
busbud logoThe cheapest trip from Milwaukee to La Crosse, WI was searched and found on Aug 30, 2025 with a price of $39

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to La Crosse, WI, as early as possible.

You can expect to pay from $39 to $54 for a bus ticket from Milwaukee to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at $39 which is on 2025-09-02.

Usually Megabus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Milwaukee and La Crosse!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Milwaukee to La Crosse.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Milwaukee to La Crosse that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Milwaukee to La Crosse, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Milwaukee to La Crosse, WI?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Milwaukee by bus?

Bus from La Crosse, WI to Milwaukee

You can also go to La Crosse, WI by train

Train from Milwaukee to La Crosse, WI

Why choose Busbud?

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