Bus Tickets from Jacksonville, FL to Florence, SC, US

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TodaySep 2
from $68
TomorrowSep 3
from $53
ThuSep 4
from $55
FriSep 5
from $55
SatSep 6
from $55
SunSep 7
from $61
MonSep 8
TueSep 9

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: September 3 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: September 4 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: September 3 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: September 3 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Jacksonville to Florence.

Bus
Average Price$48 - $82Average Duration7h
12kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$52 - $145Average Duration12h 16m
42kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Jacksonville to Florence

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 7 hours and with fares starting at just $48, it presents an excellent value for a comfortable ride.

2bus per day
7hAverage Duration
$48Cheapest ticket
12kgCO₂ emissions

Bus Jacksonville, FL to Florence, SC, US: Trip Overview

Average ticket price$59
Average bus trip duration7h
Number of daily buses2
Earliest bus departure8:45am
Distance289 miles (465 km)
Latest bus departure6:30pm

Jacksonville to Florence Bus

With Busbud, comparing and booking tickets for a bus from Jacksonville to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Jacksonville to Florence will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Jacksonville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Jacksonville, FL - Florence, SC, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$53
09/01
$53
Today
$50
09/03
$45
09/04
$47
09/05
$47
09/06
$47
09/07
$53
busbud logoThe cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on Sep 3, 2025 with a price of $45

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US, as early as possible.

You can expect to pay from $45 to $70 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $45 which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Jacksonville to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Jacksonville to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jacksonville to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Jacksonville to Florence.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Jacksonville, FL to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Jacksonville, FL by bus?

Bus from Florence, SC, US to Jacksonville, FL

You can also go to Florence, SC, US by train

Train from Jacksonville, FL to Florence, SC, US

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