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One passenger / one way
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Compare 2 ways to go from Harrisburg to St. Louis.
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 22 hours 5 minutes and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Bus Harrisburg to St. Louis: Trip Overview
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Harrisburg to St. Louis Bus
With Busbud, comparing and booking tickets for a bus from Harrisburg to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Harrisburg to St. Louis.
Discover how much the bus trip from Harrisburg to St. Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Harrisburg and St. Louis?
Frequently asked questions for your trip Harrisburg - St. Louis
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Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to St. Louis, as early as possible.
You can expect to pay from $84 to $116 for a bus ticket from Harrisburg to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $84 which is on 2025-08-30.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Harrisburg to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Harrisburg to St. Louis.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Harrisburg to St. Louis will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Harrisburg to St. Louis, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
What's the cheapest way to go from Harrisburg to St. Louis?
Top traveled bus routes
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Popular Buses Connecting Harrisburg
Buses Leaving from Harrisburg
- Bus from Harrisburg to Baltimore
- Bus Harrisburg - Allentown
- Harrisburg - Houston
- Bus from Harrisburg to Temple
- Bus Harrisburg - Chicago
- Harrisburg - Atlanta
- Bus from Harrisburg to New York City
- Bus Harrisburg - Lancaster
- Harrisburg - Washington
- Bus from Harrisburg to State College
- Bus Harrisburg - Pittsburgh
- Harrisburg - Atlantic City
- Bus from Harrisburg to Philadelphia
- Bus Harrisburg - Boston
- Harrisburg - York
Buses Going to Harrisburg
- Bus from Pittsburgh to Harrisburg
- Bus Marathon - Harrisburg
- Houston - Harrisburg
- Bus from Baltimore to Harrisburg
- Bus Temple - Harrisburg
- Orlando - Harrisburg
- Bus from New York City to Harrisburg
- Bus State College - Harrisburg
- Allentown - Harrisburg
- Bus from Lancaster to Harrisburg
- Bus Philadelphia - Harrisburg
- Washington - Harrisburg
- Bus from Newark to Harrisburg
- Bus York - Harrisburg
- Boston - Harrisburg
Popular Buses Connecting St. Louis
Buses Leaving from St. Louis
- Bus from St. Louis to New Orleans
- Bus St. Louis - Kansas City
- St. Louis - Kansas City
- Bus from St. Louis to Nashville
- Bus St. Louis - Buffalo
- St. Louis - Austin
- Bus from St. Louis to Chicago
- Bus St. Louis - Columbia
- St. Louis - Atlanta
- Bus from St. Louis to Springfield
- Bus St. Louis - Dallas
- St. Louis - Indianapolis
- Bus from St. Louis to Memphis
- Bus St. Louis - Carbondale
- St. Louis - Orlando
Buses Going to St. Louis
- Bus from Manchester to St. Louis
- Bus Manchester - St. Louis
- New Orleans - St. Louis
- Bus from Atlanta to St. Louis
- Bus Indianapolis - St. Louis
- Omaha - St. Louis
- Bus from Chicago to St. Louis
- Bus Kansas City - St. Louis
- Springfield - St. Louis
- Bus from Carbondale to St. Louis
- Bus Columbia - St. Louis
- Lafayette - St. Louis
- Bus from Nashville to St. Louis
- Bus Dallas - St. Louis
- Memphis - St. Louis
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
- Albany - New York City
- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
- Miami - Tampa
- Bus from Seattle to Leavenworth
- Bus Austin - Dallas
- Dallas - Austin
- Bus from Houston to San Antonio
- Bus Austin - Houston
- Orlando - Atlanta
- Bus from New York City to Los Angeles
- Bus Dallas - San Antonio
- Houston - Austin
Popular airport transfers
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- Bus to Harrisburg
- Bus to St. Louis
- Harrisburg to St. Louis Buses