Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Knoxville Bus Station | Lafayette Bus Stop | Cheapest | |||||
| Knoxville Bus Station | Lafayette Bus Stop | Fastest | |||||
| Knoxville Bus Station | Lafayette Bus Stop | No tags |
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Bus Knoxville, TN to Lafayette, IN: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Knoxville to Lafayette Bus
Busbud helps you find a bus from Knoxville to Lafayette. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Lafayette.
Discover how much the bus trip from Knoxville to Lafayette will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Knoxville and Lafayette?
Frequently asked questions for your trip Knoxville, TN - Lafayette, IN
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Lafayette, IN was searched and found on Aug 25, 2025 with a price of $63To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Lafayette, IN, as early as possible.
You can expect to pay from $63 to $89 for a bus ticket from Knoxville, TN to Lafayette, IN based on the last 2 days. You can expect to find the cheapest price for the trip at $63 which is on 2025-08-25.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Lafayette!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Knoxville to Lafayette.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Lafayette will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Knoxville to Lafayette, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Top traveled bus routes
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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Orlando
- Bus from Knoxville to Lexington
- Bus Knoxville - Chicago
- Knoxville - Greenville
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - New York City
- Bus from Knoxville to Memphis
- Bus Knoxville - Washington
- Knoxville - Asheville
- Bus from Knoxville to Miami
- Bus Knoxville - Jackson
- Knoxville - Cincinnati
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Atlanta to Knoxville
- Bus Asheville - Knoxville
- New York City - Knoxville
- Bus from Greenville to Knoxville
- Bus Louisville - Knoxville
- Cookeville - Knoxville
- Bus from Lexington to Knoxville
- Bus Dallas - Knoxville
- Dayton - Knoxville
Popular Buses Connecting Lafayette
Buses Leaving from Lafayette
- Bus from Lafayette to Easton
- Bus Lafayette - Indianapolis
- Lafayette - Chicago
- Bus from Lafayette to Washington
- Bus Lafayette - Detroit
- Lafayette - Montreal
- Bus from Lafayette to Champaign
- Bus Lafayette - St. Louis
- Lafayette - Bloomington
- Bus from Lafayette to Madison
- Bus Lafayette - Columbus
- Lafayette - Cincinnati
- Bus from Lafayette to South Bend
- Bus Lafayette - Nashville
Buses Going to Lafayette
- Bus from London to Lafayette
- Bus Chicago - Lafayette
- Houston - Lafayette
- Bus from New Orleans to Lafayette
- Bus Nashville - Lafayette
- Columbia - Lafayette
- Bus from Indianapolis to Lafayette
- Bus Madison - Lafayette
- Cincinnati - Lafayette
- Bus from Gary to Lafayette
- Bus Columbus - Lafayette
- Bloomington - Lafayette
- Bus from New York City to Lafayette
- Bus Champaign - Lafayette