Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Downtown Transit Center | Knoxville Bus Station | Cheapest | |||||
 | Indianapolis Bus Station | Knoxville Bus Station | Fastest | |||||
| Indianapolis Bus Station | Knoxville Bus Station | No tags | |||||
| Indianapolis Bus Station | Knoxville Bus Station | No tags |
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Bus Indianapolis to Knoxville, TN: Trip Overview
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Indianapolis to Knoxville Bus
With Busbud, comparing and booking tickets for a bus from Indianapolis to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Indianapolis to Knoxville will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Indianapolis and Knoxville?
Frequently asked questions for your trip Indianapolis - Knoxville, TN
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Knoxville, TN was searched and found on Aug 27, 2025 with a price of $55To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Knoxville, TN, as early as possible.
You can expect to pay from $55 to $86 for a bus ticket from Indianapolis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $55 which is on 2025-08-27.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Indianapolis to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Indianapolis to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Knoxville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Indianapolis to Knoxville.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Top traveled bus routes
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Popular Buses Connecting Knoxville
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Buses Going to Knoxville
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