Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Gateway Station | San Diego (Old Town-FlixBus) | Cheapest | |||||
Greyhound Lines, Inc. + FlixBus | Gateway Station | UCSD Health La Jolla Station | Fastest | |||||
Greyhound Lines, Inc. + FlixBus | Gateway Station | San Diego (Old Town-FlixBus) | No tags | |||||
 | Gateway Station | Greyhound Bus Stop | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Gateway Station | San Diego (Old Town-FlixBus) | No tags |
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Compare 2 ways to travel from St. Louis to San Diego
Busbud recommends taking the bus from St. Louis to San DiegoAmong the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 3 hours 25 minutes and with fares starting at just US$132, it presents an excellent value for a comfortable ride.
Bus St. Louis to San Diego, CA, US: Trip Overview
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St. Louis to San Diego Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.
We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in St. Louis and San Diego?
Frequently asked questions on the trip St. Louis - San Diego, CA, US
How far is San Diego from St. Louis by coach?
The journey from St. Louis to San Diego by coach covers an approximate distance of 1560 miles (2516 km).
Is there a way to reach San Diego from St. Louis without flying?
To travel from St. Louis to San Diego without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to San Diego, CA, US was searched and found on 24 Aug 2025 with a price of US$156To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US as early as possible.
You can expect to pay from US$156 to US$188 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$174, which is on 2025-08-26.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
What's the cheapest way to go from St. Louis to San Diego, CA, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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