Find coaches from Des Moines to Indianapolis

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Tomorrow5 Sept
from US$68
Sat6 Sept
from US$65
Sun7 Sept
from US$80
Mon8 Sept
from US$60
Tue9 Sept
from US$55
Wed10 Sept
Thu11 Sept
Fri12 Sept

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 5 September at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 5 September at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 5 September at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 5 September at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 5 September at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 5 September at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Des Moines to Indianapolis: Trip Overview

Average ticket priceUS$84
Average bus trip duration12h 20m
Number of daily buses2
Earliest bus departure05:30
Distance410 miles
Latest bus departure08:15

Des Moines to Indianapolis Bus

Busbud helps you find a bus from Des Moines to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to Indianapolis.

From cheap bus tickets to more luxurious buses travelling from Des Moines to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Des Moines - Indianapolis

  1. How far is Indianapolis from Des Moines by coach?

    The distance between Des Moines and Indianapolis by coach is approximately 410 miles (661 km).

  2. Is there a way to reach Indianapolis from Des Moines without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
02/09
US$61
03/09
No data
Today
US$80
05/09
US$61
06/09
US$58
07/09
US$72
08/09
US$53
09/09
US$48
busbud logoThe cheapest trip from Des Moines to Indianapolis was searched and found on 9 Sept 2025 with a price of US$48

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Indianapolis as early as possible.

You can expect to pay from US$48 to US$173 for a bus ticket from Des Moines to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$48, which is on 2025-09-09.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to Indianapolis.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Des Moines to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Des Moines by bus?

Bus from Indianapolis to Des Moines

Why choose Busbud?

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