Bus Tickets from St. Louis to Harrisburg

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TodayAug 28
from US$129
TomorrowAug 29
SatAug 30
SunAug 31
MonSep 1
TueSep 2
WedSep 3
ThuSep 4

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 28 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: August 29 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 28 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: August 30 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 28 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: August 30 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 28 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: August 30 at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from St. Louis to Harrisburg

Bus
Average PriceUS$91 - US$269Average Duration21h 25m
29kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$181 - US$322Average Duration1d 3h
105kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to Harrisburg

Among the sustainable travel choices, the bus stands out as a good way to reach Harrisburg. The journey takes about 21 hours 25 minutes, and with fares starting at just US$91, it presents an excellent value for a comfortable ride.

7bus per day
21h 25mAverage Duration
US$91Cheapest ticket
29kgCO₂ emissions

Bus St. Louis to Harrisburg: Trip Overview

Average Ticket PriceUS$122
Average Bus Trip Duration21h 25m
Number of daily buses7
Earliest bus departure2:00am
Distance1157 km
Latest bus departure11:30pm

St. Louis to Harrisburg Bus

Busbud helps you find a bus from St. Louis to Harrisburg. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from St. Louis to Harrisburg will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Harrisburg, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Harrisburg

  1. What is the distance between St. Louis and Harrisburg?

    The distance between St. Louis and Harrisburg is approximately 1158 km (718 miles).

  2. What are the departure and arrival locations for buses traveling from St. Louis to Harrisburg?

    Buses departing from Gateway Station in St. Louis will take you to Harrisburg Bieber Greyhound Station in Harrisburg.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-26
No data
08-27
No data
Today
US$103
08-29
No data
08-30
US$83
08-31
No data
09-01
No data
09-02
No data
busbud logoThe cheapest trip from St. Louis to Harrisburg was searched and found on Aug 30, 2025 with a price of US$83

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Harrisburg, as early as possible.

You can expect to pay from US$83 to US$139 for a bus ticket from St. Louis to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at US$83 which is on 2025-08-30.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Harrisburg!

Much more than a mere vehicle taking you from St. Louis to Harrisburg, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Harrisburg that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Harrisburg while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from St. Louis to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Harrisburg to St. Louis

You can also go to Harrisburg by train

Train from St. Louis to Harrisburg

Why choose Busbud?

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