Bus Tickets from Durham, NC, US to Florence, SC, US

Find affordable bus tickets from Durham, NC, US to Florence, SC, US with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.

Previously seen trips

One passenger / one way

  • Departure time: September 18 at
    Departure city: Durham
    Departure location: BP Gas Station
    Arrival time: September 18 at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 19 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: October 19 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: October 20 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: October 26 at
    Departure city: Durham
    Departure location: BP Gas Station
    Arrival time: October 26 at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: October 26 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: October 27 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Durham to Florence

Bus
Average PriceUS$38 - US$75Average Duration3h 40m
5kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$45 - US$70Average Duration8h 25m
20kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Durham to Florence

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 3 hours 40 minutes, and with fares starting at just US$38, it presents an excellent value for a comfortable ride.

2bus per day
3h 40mAverage Duration
US$38Cheapest ticket
5kgCO₂ emissions

Bus Durham, NC, US to Florence, SC, US: Trip Overview

Average Ticket PriceUS$67
Average Bus Trip Duration3h 40m
Number of daily buses2
Earliest bus departure4:20am
Distance215 km
Latest bus departure9:15pm

Durham to Florence Bus

Busbud helps you find a bus from Durham to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Durham to Florence from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Durham, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Durham, NC, US - Florence, SC, US

  1. What is the travel distance from Durham to Florence?

    The distance between Durham and Florence is around 210 km (131 miles).

  2. What are the departure and arrival locations for buses traveling from Durham to Florence?

    Buses traveling this route start their trip at Durham Greyhound Bus Station, in Durham, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-01
US$40
09-02
US$60
Today
US$49
09-04
No data
09-05
No data
09-06
No data
09-07
No data
09-08
No data
busbud logoThe cheapest trip from Durham, NC, US to Florence, SC, US was searched and found on Sep 1, 2025 with a price of US$40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Florence, SC, US, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Durham and Florence!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Durham to Florence, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Durham to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Durham to Florence.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Durham, NC, US by bus?

Bus from Florence, SC, US to Durham, NC, US

You can also go to Florence, SC, US by train

Train from Durham, NC, US to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Durham

Buses Leaving from Durham

Buses Going to Durham

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence