Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Des Moines (Subway) | Chicago 95Th & Dan Ryan | Cheapest | |||||
 | Des Moines (Subway) | Downtown Greyhound Station | Fastest | |||||
| Des Moines (Subway) | Downtown Greyhound Station | No tags |
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Bus Des Moines to Chicago: Trip Overview
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Des Moines to Chicago Bus
With Busbud, comparing and booking tickets for a bus from Des Moines to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Des Moines to Chicago from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Des Moines to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Des Moines and Chicago?
Frequently asked questions on the trip Des Moines - Chicago
What is the distance between Des Moines and Chicago?
Des Moines and Chicago are 496 km (308 miles) apart.
What are the departure and arrival locations for buses traveling from Des Moines to Chicago?
Buses departing from Jefferson/Trailways Depot in Des Moines will take you to Downtown Greyhound Station in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Chicago was searched and found on Sep 6, 2025 with a price of US$43To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago, as early as possible.
You can expect to pay from US$43 to US$173 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$43 which is on 2025-09-06.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Des Moines to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to Chicago, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Chicago that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Des Moines to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Top travelled bus routes
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Popular Buses Connecting Des Moines
Buses Leaving from Des Moines
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Buses Going to Des Moines
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- Bus from Los Angeles to Des Moines
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Popular Buses Connecting Chicago
Buses Leaving from Chicago
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Buses Going to Chicago
- Bus from Boston to Chicago
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- Bus from Savannah to Chicago
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- St. Louis - Chicago
Popular routes in this country
- Bus from Washington to New York City
- Bus Boston - New York City
- New York City - Boston
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- Atlanta - Savannah