Bus Tickets from Chicago to Tupelo

Find affordable bus tickets from Chicago to Tupelo with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayAug 31
TomorrowSep 1
TueSep 2
from US$74
WedSep 3
from US$65
ThuSep 4
FriSep 5
SatSep 6
from US$73
SunSep 7

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 2 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 2 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 2 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 3 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 2 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 3 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 3 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Chicago to Tupelo: Trip Overview

Average Ticket PriceUS$109
Average Bus Trip Duration22h 55m
Number of daily buses5
Earliest bus departure6:10am
Distance854 km
Latest bus departure11:59pm

Chicago to Tupelo Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Tupelo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Tupelo.

Discover how much the bus trip from Chicago to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Tupelo

  1. How far is Chicago from Tupelo?

    The distance covered from Chicago to Tupelo is 853 km (529 miles).

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
No data
08-30
No data
Today
No data
09-01
No data
09-02
US$77
09-03
US$66
09-04
No data
09-05
No data
busbud logoThe cheapest trip from Chicago to Tupelo was searched and found on Sep 3, 2025 with a price of US$66

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.

You can expect to pay from US$66 to US$103 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$66 which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Tupelo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Tupelo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Tupelo will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Chicago to Tupelo while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Chicago by bus?

Bus from Tupelo to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Chicago

Buses Leaving from Chicago

Buses Going to Chicago

Popular Buses Connecting Tupelo

Buses Leaving from Tupelo

Buses Going to Tupelo