Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Chicago 95Th & Dan Ryan | Spartanburg | Cheapest | |||||
 | Chicago 95Th & Dan Ryan | Spartanburg | Fastest | |||||
 | Downtown Greyhound Station | Spartanburg | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Downtown Greyhound Station | Spartanburg | No tags | |||||
| Chicago 95Th & Dan Ryan | Spartanburg | No tags |
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Compare 2 ways to go from Chicago to Spartanburg
Busbud recommends taking the bus from Chicago to SpartanburgAmong the sustainable travel choices, the bus stands out as a good way to reach Spartanburg. The journey takes about 22 hours, and with fares starting at just US$94, it presents an excellent value for a comfortable ride.
Bus Chicago to Spartanburg: Trip Overview
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Chicago to Spartanburg Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Chicago to Spartanburg.
Bus service from Chicago to Spartanburg will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Spartanburg from Chicago, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Chicago and Spartanburg?
Frequently asked questions on the trip Chicago - Spartanburg
What is the travel distance from Chicago to Spartanburg?
Chicago and Spartanburg are 916 km (568 miles) apart.
What are the departure and arrival locations for buses traveling from Chicago to Spartanburg?
Buses departing from Downtown Greyhound Station in Chicago will take you to Super Acapulco in Spartanburg.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Spartanburg was searched and found on Aug 22, 2025 with a price of US$87To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Spartanburg, as early as possible.
You can expect to pay from US$87 to US$173 for a bus ticket from Chicago to Spartanburg based on the last 2 days. You can expect to find the cheapest price for the trip at US$90 which is on 2025-08-26.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Chicago to Spartanburg but it'll also be endearing to native speakers who will surely appreciate your effort.
Much more than a mere vehicle taking you from Chicago to Spartanburg, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Spartanburg.
Make a music playlist for your bus ride from Chicago to Spartanburg, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
What's the cheapest way to go from Chicago to Spartanburg?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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